Action of Bradykinin on Human Pulmonary Circulation
نویسندگان
چکیده
منابع مشابه
Noscapine antagonizes vasoconstrictor action of bradykinin in isolated human umbilical artery
Abstract Background: It has been demonstrated that noscapine, an antitussive opioid alkaloid, could antagonize bradykinin- induced responses such as bradykinin effects in guinea-pig ileum, cough induced by bradykinin receptor agonist and angiotensin converting enzyme inhibitors, and brain damage after brain edema both in neonatal rat model and in patients with stroke. In the present study, the...
متن کاملAction of Bradykinin
BRADYKININ acts as a powerful vasodilator upon the systemic circulation.'-10 Contradictory reports, however, have been published concerning its effect on the pulmonary vascular bed. In different studies carried out in various animal species, the drug has been reported as eliciting either dilatation7' 11 or constriction12 of the pulmonary vessels. Gersmeyer and Spitzbarth6 observed a rise in pul...
متن کاملSite of action of hypertonic saline in the pulmonary circulation.
THE INTRAVENOUS INJECTION of 20 per cent saline to open-chest dogs has been shown to cause a marked though transient rise of pulmonary arterial pressure, attributed to spasm of the pulmonary arterioles.' Subsequently we demonstrated that the intravenous administration of hypertonic saline causes, in addition, a marked rise of pulmonary venous pressure and a fall or no change of left atrial pres...
متن کاملnoscapine antagonizes vasoconstrictor action of bradykinin in isolated human umbilical artery
abstract background: it has been demonstrated that noscapine, an antitussive opioid alkaloid, could antagonize bradykinin- induced responses such as bradykinin effects in guinea-pig ileum, cough induced by bradykinin receptor agonist and angiotensin converting enzyme inhibitors, and brain damage after brain edema both in neonatal rat model and in patients with stroke. in the present study, the ...
متن کاملCharacterization of the vasodilatory action of testosterone in the human pulmonary circulation
AIM To assess for the first time the vasodilatory effect of testosterone in the human pulmonary circulation utilizing both isolated human pulmonary arteries and isolated perfused human lungs. In addition, a secondary aim was to determine whether there was any difference in the response to testosterone dependent upon gender. METHODS Isolated human pulmonary arteries were studied by wire myogra...
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ژورنال
عنوان ژورنال: Circulation
سال: 1966
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.34.3.385